反应详情

98 mg (0.39 mmol) of 3-[4-(4-fluoro-phenyl)-thiazol-2-yl]-acrylic acid, 79.6 mg (0.78 mmol) of diisopropylamine, 119.35 mg (1.17 mmol) of triethylamine and 164.5 mg (0.43 mmol) of HATU in 5 ml of DMF were stirred at room temperature for 2 h. The reaction mixture was concentrated, and water and ethyl acetate were added. The organic phase was separated, washed and evaporated. The residue was purified by chromatography (RP18). Yield: 39 mg.

1. concentrationThe reaction mixture was concentrated
2. additionwater and ethyl acetate were added
3. customThe organic phase was separated
4. washwashed
5. customevaporated
6. customThe residue was purified by chromatography (RP18)