Hydrazine hydrate (1:1) → 3-[3-(benzyloxy)-4-methoxyphenyl]-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one

HRID 1873793Notes

Reaction equation

HRID 1873793 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17](=O)[C:18]([CH3:24])([CH3:23])[C:19](OC)=[O:20])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:27][NH2:28]>>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:17]2[C:18]([CH3:24])([CH3:23])[C:19](=[O:20])[NH:27][N:28]=2)[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 66616508Methyl 3-[3-(benzyloxy)-4-methoxyphenyl]-2,2-dimethyl-3-oxopropanoate2×

Product 1

HCID 666165693-[3-(benzyloxy)-4-methoxyphenyl]-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one

Procedure

Prepared analogously as described for example C1 using methyl 3-[3-(benzyloxy)-4-methoxyphenyl]-2,2-dimethyl-3-oxopropanoate (compound D4) and hydrazine hydrate as starting compounds.

Workup

  1. customPrepared analogously

Sources & evidence

ORD record
ord-0cfa1e2a2a2340378faebdc94b759309
Source dataset
uspto-grants-2012_11
Patent number
US08304436B2

Reaction notes

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