反应详情

A solution of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carbonyl chloride (195 mg, 1.0 mmol) in dichloromethane (2 ml) was added dropwise to a stirred solution of (234 mg, 1.0 mmol) 2-(2,4-dichloro-phenyl)-2-methoxy-1-methyl-ethylamine, which was prepared as described in example P2, and triethylamine (202 mg, 2.0 mmol) in dichloromethane (6 ml) at 0° C. The reaction mixture was stirred for 1 hr at ambient temperature then allowed to stand for 4 h. After removal of the solvent the residue was purified by flash chromatography over silica gel (eluant:hexane/ethyl acetate 1:1). 170 mg (43% of theory) of 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid [2-(2,4-dichlorophenyl)-2-methoxy-1-methyl-ethyl]-amide was obtained in the form of a resin as a mixture of diastereomeres.

1. customwas prepared
2. waitto stand for 4 h
3. customAfter removal of the solvent the residue
4. customwas purified by flash chromatography over silica gel (eluant:hexane/ethyl acetate 1:1)