Benzyl Bromide → Piperidinium, 1-methyl-4-oxo-1-(phenylmethyl)-, bromide

HRID 1873930Notes

Reaction equation

HRID 1873930 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1.[Br:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>CC(C)=O>[Br-:9].[CH2:10]([N+:2]1([CH3:1])[CH2:7][CH2:6][C:5](=[O:8])[CH2:4][CH2:3]1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 2

HCID 7498Benzyl BromideHCID 740491-Methyl-4-piperidone

Product 1

HCID 10802960Piperidinium, 1-methyl-4-oxo-1-(phenylmethyl)-, bromide

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

To a solution of 1-methyl-4-piperidinone (15 g, 132.6 mmol) in dry acetone (100 mL) was added 1-bromomethylbenzene (24.9 g, 145 mmol) dropwise. It was stirred for 3 h. The title compound (116) separated which was filtered, washed with dry acetone and dried.

Workup

  1. customThe title compound (116) separated which
  2. filtrationwas filtered
  3. washwashed with dry acetone
  4. customdried

Sources & evidence

ORD record
ord-774e517dc66d4d2da3bb2f1df1ddd55c
Source dataset
uspto-grants-2012_11
Patent number
US08304449B2

Reaction notes

Loading…