反应详情

温度

0 °C

Next, oxalyl chloride (52.2 g; 0.41 mol) was dissolved in CHCl3 (1000 ml), and cooled to 0° C. To this was slowly added a solution of 6(benzyloxy)-6-oxohexanoic acid, (81.0 g; 0.34 mol) in CHCl3 (250 ml), and stirring was continued for 18 hr at room temperature. The reaction mixture was concentrated, coevaporated with CHCl3 (2 times 250 ml), and dried in vacuo, to yield benzyl 6-chloro-6-oxohexanoate as a colourless liquid (87 g; 100%).

1. concentrationThe reaction mixture was concentrated
2. customdried in vacuo