Water → HCID 135869960, compound

HRID 1873959Notes

Reaction equation

HRID 1873959 reaction equation
O.C([O:9][C:10]1[CH:18]=[C:17]2[C:13]([C:14]([CH:25]([O:27][CH3:28])[CH3:26])=[N:15][N:16]2[CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][O:20]2)=[CH:12][CH:11]=1)C1C=CC=CC=1.[H][H]>[Pd].C1COCC1>[CH3:28][O:27][CH:25]([C:14]1[C:13]2[C:17](=[CH:18][C:10]([OH:9])=[CH:11][CH:12]=2)[N:16]([CH:19]2[CH2:24][CH2:23][CH2:22][CH2:21][O:20]2)[N:15]=1)[CH3:26]

Participants

6

Reactant 3

HCID 962WaterHCID 45280133HCID 45280133, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 135869960HCID 135869960, compoundYield 113.6%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

5% Palladium on carbon-STD-type-50% wet with water (79.5 mg; manufactured by N. E. Chemcat Corp.) and 6-(benzyloxy)-3-(1-methoxyethyl)-1-(tetrahydro-2H-pyran-2-yl)-indazole (195 mg) which can be prepared according to the method described in Reference example 25, etc. were dissolved in THF (5.6 mL; manufactured by Kanto Chemical Co., Inc.). After replacing the reaction system with hydrogen, it was stirred overnight at room temperature under hydrogen atmosphere. After replacing the reaction solution with nitrogen, the mixture was filtered and the filtrate was concentrated under reduced pressure to obtain the title compound (167 mg).

Workup

  1. customcan be prepared
  2. filtrationthe mixture was filtered
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-57816e46788645d2932bb99c71ab65df
Source dataset
uspto-grants-2012_11
Patent number
US08304443B2

Reaction notes

Loading…