Water → Benzyl 2-(1-benzyl-3-cyclopropylindazol-6-yloxy)ethylcarbamate

Participants

Reaction Conditions

Reaction Steps

Benzyl 2-bromoethylcarbamate (1.0563 g) which can be prepared according to the method described in Reference example 40, etc. was dissolved in dehydrated DMF (5 mL), added with 1-benzyl-3-cyclopropylindazol-6-ol (533.4 mg) which can be prepared according to the method described in Reference example 3, etc. and potassium carbonate (879.1 mg), and stirred overnight at 50° C. under nitrogen atmosphere. After cooling to room temperature, the reaction solution was added to water and extraction was carried out twice with ethyl acetate. The organic layer was washed twice with water and once with brine and dried over sodium sulfate. After the solvent was evaporated under reduced pressure, the resulting reside was purified by column chromatography (“COLUMN-B”; n-hexane:ethyl acetate=81:19→60:40) to obtain the title compound as a crude product (508.2 mg).

Provenance & Evidence