反应详情

温度

50 °C

Benzyl 2-bromoethylcarbamate (1.0563 g) which can be prepared according to the method described in Reference example 40, etc. was dissolved in dehydrated DMF (5 mL), added with 1-benzyl-3-cyclopropylindazol-6-ol (533.4 mg) which can be prepared according to the method described in Reference example 3, etc. and potassium carbonate (879.1 mg), and stirred overnight at 50° C. under nitrogen atmosphere. After cooling to room temperature, the reaction solution was added to water and extraction was carried out twice with ethyl acetate. The organic layer was washed twice with water and once with brine and dried over sodium sulfate. After the solvent was evaporated under reduced pressure, the resulting reside was purified by column chromatography (“COLUMN-B”; n-hexane:ethyl acetate=81:19→60:40) to obtain the title compound as a crude product (508.2 mg).

1. customcan be prepared
2. temperatureAfter cooling to room temperature
3. washThe organic layer was washed twice with water and once with brine
4. dry with materialdried over sodium sulfate
5. customAfter the solvent was evaporated under reduced pressure
6. customthe resulting reside was purified by column chromatography (“COLUMN-B”; n-hexane:ethyl acetate=81:19→60:40)