反应详情

N-Benzyl-2-(benzyloxy)ethane amine (13.6532 g) which can be prepared according to the method described in Reference example 56, etc. was added with (R)-2-(3-nitrophenyl)oxirane (20.21 g) and 2-propanol (205 mL), followed by stirring for 36 hours at reflux. After cooling to room temperature, the reaction solution was concentrated under reduced pressure. Toluene (100 mL) was added to the residue and the mixture was concentrated under reduced pressure. The resulting residue was purified by column chromatography (“COLUMN-D”; n-hexane:ethyl acetate=85:15→80:20) to obtain the title compound (30.761 g).

1. temperatureat reflux
2. concentrationthe reaction solution was concentrated under reduced pressure
3. additionToluene (100 mL) was added to the residue
4. concentrationthe mixture was concentrated under reduced pressure
5. customThe resulting residue was purified by column chromatography (“COLUMN-D”; n-hexane:ethyl acetate=85:15→80:20)