Acetic Anhydride → HCID 67005461, compound

HRID 1873985Notes

Reaction equation

HRID 1873985 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([CH2:9][C:10](=[O:14])[NH:11]2)=[CH:7][CH:6]=1)=[O:4].[CH3:15][O:16][C:17](OC)(OC)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.CC(OC(C)=O)=O>>[CH3:15][O:16][C:17]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[C:9]1[C:8]2[C:12](=[CH:13][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:6][CH:7]=2)[NH:11][C:10]1=[O:14]

Participants

4

Reactant 3

HCID 7918Acetic AnhydrideHCID 69720Trimethyl orthobeznoateHCID 37343722-Oxindole-6-carboxylic acid methyl ester

Product 1

HCID 67005461HCID 67005461, compound

Procedure

Alternatively, the 6-methoxycarbonyl-2-oxindole may be reacted directly with trimethylorthobenzoate in the presence of acetanhydride to obtain the “enolether” (methyl 3-[methoxy(phenyl)methylene]-2-oxoindoline-6-carboxylate). This alternative embodiment is described in the General Synthesis Scheme as step II′ and may be carried out as described above for step IIb.

Sources & evidence

ORD record
ord-67b4fde467b84c23acc09f2c555c6fb2
Source dataset
uspto-grants-2012_11
Patent number
US08304541B2

Reaction notes

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