Cesium carbonate → HCID 57749110, compound

HRID 1874325Notes

Reaction equation

HRID 1874325 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].Br[C:13]1[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[N:17][CH:18]=1.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:13]2[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[N:17][CH:18]=2)=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

Participants

5

Reactant 3

HCID 10796Cesium carbonateHCID 691274-Chloro-3-nitrophenolHCID 8176205-Bromo-2-nitropyridine

Product 1

HCID 57749110HCID 57749110, compoundYield 52.4%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same manner as in Reference Example 1 and using 4-chloro-3-nitrophenol (4.70 g, 27.1 mmol), 5-bromo-2-nitropyridine (5.00 g, 24.6 mmol), cesium carbonate (12.0 g, 36.9 mmol) and N,N-dimethylformamide (50 mL) as starting materials, the title compound (3.81 g, 52%) was obtained as a yellow solid.

Sources & evidence

ORD record
ord-148fb80bdd6b42659cecf2551038deb3
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

Loading…