Ethyl isothiocyanatoformate → Ethyl {[(5-methoxypyridin-2-yl)amino]carbonothioyl}carbamate

HRID 1874352Notes

Reaction equation

HRID 1874352 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[N:10]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:11]=[S:12]>CS(C)=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:11]([NH:10][C:13](=[O:14])[O:15][CH2:16][CH3:17])=[S:12])=[N:7][CH:8]=1

Participants

4

Reactant 2

HCID 85320Ethyl isothiocyanatoformateHCID 113209342-Amino-5-methoxypyridine

Product 1

HCID 58087980Ethyl {[(5-methoxypyridin-2-yl)amino]carbonothioyl}carbamateYield 62.3%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

In the same manner as in Reference Example 30 and using 5-methoxypyridin-2-amine (1.05 g, 8.43 mmol), DMSO (5 mL) and ethyl isothiocyanatoformate (1.44 g, 11.0 mmol) as starting materials, the title compound (1.34 g, 62%) was obtained as a white solid.

Sources & evidence

ORD record
ord-d17d96f9c49d44fb8712564c06747c51
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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