反应详情

A mixture of 6-methoxy[1,2,4]triazolo[1,5-a]pyridin-2-amine (780 mg, 4.75 mmol) and 48% hydrobromic acid (3 mL) was stirred under refluxing conditions for 7 hr. 48% Hydrobromic acid (2 mL) was further added, and the mixture was stirred with heating under reflux for 3 hr. The mixture was concentrated under reduced pressure, and diisopropyl ether (2 mL) and ethanol (1 mL) were added to the residue. The precipitate was collected by filtration and washed with diisopropyl ether to give the title compound (984 mg, 89%) as a brown solid.

1. stirringthe mixture was stirred
2. temperaturewith heating
3. temperatureunder reflux for 3 hr
4. concentrationThe mixture was concentrated under reduced pressure, and diisopropyl ether (2 mL) and ethanol (1 mL)
5. additionwere added to the residue
6. filtrationThe precipitate was collected by filtration
7. washwashed with diisopropyl ether