Hydrochloric Acid → 6-Chloro-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one

HRID 187436Notes

Reaction equation

HRID 187436 reaction equation
[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH:11]3[CH2:12][CH2:13][N:14]([C:17]([O:18][CH2:19][CH3:20])=[O:21])[CH2:15][CH2:16]3)[c:8](=[O:10])[nH:9]2)[cH:22]1.[ClH:23].[Na+:25].[OH-:24]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([n:7]([CH:11]3[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]3)[c:8](=[O:10])[nH:9]2)[cH:22]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 961HydroxideHCID 13792190Ethyl 4-(6-chloro-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)-1-piperidinecarboxylate

Product 1

HCID 137921086-Chloro-1-piperidin-4-yl-1,3-dihydro-benzoimidazol-2-one

Sources & evidence

ORD record
ord-68a624d73cb346139dbc848c04d88728
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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