Hydrochloric Acid → HCID 57749118, compound

HRID 1874371Notes

Reaction equation

HRID 1874371 reaction equation
C(O[CH:4]=[CH:5][CH2:6][CH3:7])C.Cl[C:9](Cl)(Cl)[C:10](Cl)=[O:11].Cl.[CH3:16][NH:17][NH2:18].[CH2:19]([OH:21])[CH3:20]>C(OCC)C.N1C=CC=CC=1>[CH2:6]([C:5]1[C:20]([C:19]([O:11][CH2:10][CH3:9])=[O:21])=[N:18][N:17]([CH3:16])[CH:4]=1)[CH3:7]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 702EthanolHCID 6061MethylhydrazineHCID 6420Trichloroacetyl chlorideHCID 1383751-ethoxybut-1-ene

Product 1

HCID 57749118HCID 57749118, compoundYield 1.1%

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 3283Diethyl EtherSolvent

Procedure

In the same manner as in Reference Example 51 and using 1-ethoxybut-1-en (25.0 g, 250 mmol), pyridine (18.2 mL), trichloroacetyl chloride (25.3 mL, 226 mmol), diethyl ether (100 mL), 0.2N hydrochloric acid (200 mL), methylhydrazine (12.6 g, 273 mmol) and ethanol (220 mL) as starting materials, the title compound (470 mg, 1.1%) was obtained as a colorless oil.

Sources & evidence

ORD record
ord-e31417686195481f829db0cc75612cde
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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