Ethanol → HCID 57749150, compound

HRID 1874476Notes

Reaction equation

HRID 1874476 reaction equation
C(OC(=O)[NH:5][C:6]([NH:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2[CH:21]=[CH:20][C:19]([F:22])=[C:18]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH:17]=2)=[CH:11][N:10]=1)=S)C.[Cl-].O[NH3+].C([N:38](CC)C(C)C)(C)C.C(O)C>CO>[NH2:38][C:6]1[N:8]=[C:9]2[CH:14]=[CH:13][C:12]([O:15][C:16]3[CH:21]=[CH:20][C:19]([F:22])=[C:18]([NH:23][C:24](=[O:25])[O:26][C:27]([CH3:29])([CH3:28])[CH3:30])[CH:17]=3)=[CH:11][N:10]2[N:5]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 21645Hydroxylamine HClHCID 81531DiisopropylethylamineHCID 57749277HCID 57749277, compound

Product 1

HCID 57749150HCID 57749150, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In the same manner as in Example 23-1 and using ethyl{[(5-{3-[(tert-butoxycarbonyl)amino]-4-fluorophenoxy}pyridin-2-yl)amino]carbonothioyl}carbamate (13.5 g, 30.0 mmol), hydroxylammonium chloride (14.7 g, 212 mmol), N,N-diisopropylethylamine (26.2 mL, 150 mmol), ethanol (75 mL) and methanol (75 mL) as starting materials, the title compound (9.00 g, 84%) was obtained as a white solid.

Sources & evidence

ORD record
ord-c82462ecd5344a2383fb4f6ed617abe5
Source dataset
uspto-grants-2012_11
Patent number
US08304557B2

Reaction notes

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