反应详情

Methyl 6-(methyloxy)-1H-indole-2-carboxylate (0.025 g, 0.13 mmol) was dissolved in THF:methanol:water/1:1:1 (3 mL) and lithium hydroxide (0.01 g, 0.38 mmol) was added. The reaction was stirred for 1 h, at which time another portion of lithium hydroxide (0.01 g, 0.38 mmol) was added. The reaction was stirred for 1 h, acidified with 10% aqueous citric acid to pH 4-5 and extracted with EtOAc (3×5 mL). The organic extracts were combined, dried over Na2SO4, filtered and evaporated. To the crude intermediate was added 3-{[5-(aminomethyl)-2-chlorophenyl]oxy}-5-chlorobenzonitrile (0.025 g, 0.085 mmol), DIPEA (0.025 mL, 0.13 mmol) and DMF (1 mL) and then stirred overnight. Purification was accomplished by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA). The desired fractions were neutralized and extracted with EtOAc. The combined organics were dried over Na2SO4, filtered and evaporated to afford the title compound (0.015 g, 26%) as a tan solid. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.38 (d, 1H), 8.88-8.93 (m, 1H), 7.77 (d, 1H), 7.59 (d, 1H), 7.42-7.48 (m, 2H), 7.35 (d, 1H), 7.26 (dd, 1H), 7.23 (d, 1H), 7.04 (d, 1H), 6.84 (d, 1H), 6.66 (dd, 1H), 4.47 (d, 2H), 3.73 (s, 3H). MS: m/z 466.2 (M+1).

1. additionwas added
2. extractionextracted with EtOAc (3×5 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated
6. stirringstirred overnight
7. customPurification
8. extractionextracted with EtOAc
9. dry with materialThe combined organics were dried over Na2SO4
10. filtrationfiltered
11. customevaporated