Trifluoroacetic acid → 5-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate

HRID 1874818Notes

Reaction equation

HRID 1874818 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([CH2:15][NH:16][C:17]([C:19]2[NH:20][C:21]3[C:26]([CH:27]=2)=[CH:25][C:24]([NH:28]C(=O)OC(C)(C)C)=[CH:23][CH:22]=3)=[O:18])=[C:11]([F:36])[C:10]=1[O:37][C:38]1[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]([Cl:46])[CH:39]=1>ClCCl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:28][C:24]1[CH:25]=[C:26]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19]([C:17]([NH:16][CH2:15][C:12]1[CH:13]=[CH:14][C:9]([Cl:8])=[C:10]([O:37][C:38]3[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]([Cl:46])[CH:39]=3)[C:11]=1[F:36])=[O:18])=[CH:27]2

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 594514661,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate

Product 1

HCID 866448845-amino-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetateYield 44.2%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (0.5 ml, 6.49 mmol) was added to a suspension of 1,1-dimethylethyl (2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate (0.038 g, 0.066 mmol) in dichloromethane (2 mL). The resulting solution was stirred at RT for 2 h. The solvent was evaporated and the residue was purified by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA) to give the title compound (0.017 g, 44%) as a white solid. 1H NMR (400 MHz, DMSO-d6): δ ppm 11.85 (s, 1H), 9.57 (br. s., 2H), 9.07 (s, 1H), 7.78 (s, 1H), 7.41-7.57 (m, 5H), 7.32-7.41 (m, 1H), 7.17 (s, 1H), 6.99-7.13 (m, 1H), 4.53 (s, 2H). MS: m/z 469 (M+1).

Workup

  1. customThe solvent was evaporated
  2. customthe residue was purified by Reverse-Phase HPLC (water/acetonitrile with 0.1% TFA)

Sources & evidence

ORD record
ord-409b75deb2fb412f9b6f593722f755a8
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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