Hydrochloric Acid → N-[[3-ethynyl-5-fluoro-4-(methanesulfonamido)phenyl]methyl]-3-[2-propan-2-yl-6-(trifluoromethyl)pyridin-3-yl]prop-2-enamide

HRID 187496Notes

Reaction equation

HRID 187496 reaction equation
[CH:18]([CH3:19])([CH3:20])[c:21]1[n:22][c:23]([C:32]([F:33])([F:34])[F:35])[cH:24][cH:25][c:26]1[CH:27]=[CH:28][C:29](=[O:30])[OH:31].[ClH:17].[NH2:1][CH2:2][c:3]1[cH:4][c:5]([F:16])[c:6]([NH:11][S:12](=[O:13])(=[O:14])[CH3:15])[c:7]([C:9]#[CH:10])[cH:8]1>>[NH:1]([CH2:2][c:3]1[cH:4][c:5]([F:16])[c:6]([NH:11][S:12](=[O:13])(=[O:14])[CH3:15])[c:7]([C:9]#[CH:10])[cH:8]1)[C:29]([CH:28]=[CH:27][c:26]1[c:21]([CH:18]([CH3:19])[CH3:20])[n:22][c:23]([C:32]([F:33])([F:34])[F:35])[cH:24][cH:25]1)=[O:30]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 59389713N-(4-Aminomethyl-2-ethynyl-6-fluoro-phenyl)-methanesulfonamideHCID 68784539HCID 68784539, compound

Product 1

HCID 72335631N-[[3-ethynyl-5-fluoro-4-(methanesulfonamido)phenyl]methyl]-3-[2-propan-2-yl-6-(trifluoromethyl)pyridin-3-yl]prop-2-enamide

Sources & evidence

ORD record
ord-d9032e541bce4e7da5ac3c2a395106ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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