Trifluoroacetic acid → 5-amino-3-bromo-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetate

HRID 1875041Notes

Reaction equation

HRID 1875041 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[Br:8][C:9]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([NH:18]C(=O)OC(C)(C)C)[CH:16]=2)[NH:11][C:10]=1[C:26]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([O:37][C:38]2[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]([Cl:46])[CH:39]=2)[C:31]=1[F:47])=[O:27]>C(Cl)(Cl)Cl>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[NH2:18][C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]([C:26]([NH:28][CH2:29][C:30]1[CH:35]=[CH:34][C:33]([Cl:36])=[C:32]([O:37][C:38]3[CH:43]=[C:42]([C:44]#[N:45])[CH:41]=[C:40]([Cl:46])[CH:39]=3)[C:31]=1[F:47])=[O:27])=[C:9]2[Br:8]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 866449141,1-dimethylethyl (3-bromo-2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate

Product 1

HCID 866449155-amino-3-bromo-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-indole-2-carboxamide trifluoroacetateYield 119.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Trifluoroacetic acid (0.5 mL, 6.49 mmol) was added to a suspension of 1,1-dimethylethyl (3-bromo-2-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-indol-5-yl)carbamate (0.082 g, 0.126 mmol) in chloroform (2 mL). The resulting solution was stirred at room temperature overnight. The solvent was evaporated to give the title compound (0.100 g, 107%). 1H NMR (400 MHz, DMSO-d6) δ ppm 12.34 (s, 1H), 9.86 (br. s., 2 H), 8.66 (t, 1H), 7.78-7.84 (m, 1H), 7.56 (t, 1H), 7.41-7.52 (m, 5H), 7.25 (dd, 1H), 4.49-4.72 (m, 2H).

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-bfaea1d8b4c44ac3981e5886cbad6083
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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