反应详情

TFA (3.30 μl, 0.043 mmol) was added to a solution of bis(1,1-dimethylethyl)(4-bromo-5-{[({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-imidazol-2-yl)imidodicarbonate (0.030 g, 0.043 mmol) in dichloromethane (2 mL). The mixture was stirred at RT overnight. The solvent was evaporated and the residue was purified by reverse phase HPLC (acetonitrile:water with 0. % TFA) to give the title compound (11 mg, 41%) as a white solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.02-8.12 (m, 1H), 7.80 (s, 1H), 7.46-7.53 (m, 2H), 7.44 (s, 1H), 7.35 (t, 1H), 6.61 (br. s., 2H), 4.47 (s, 2H). ES MS m/z 499.

1. customThe solvent was evaporated
2. customthe residue was purified by reverse phase HPLC (acetonitrile:water with 0. % TFA)