6-Chloro-2-fluoro-3-methylphenol → HCID 86644936, compound

HRID 1875134Notes

Reaction equation

HRID 1875134 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[C:6]([F:9])[C:5]([CH3:10])=[CH:4][CH:3]=1.[Cl:11][C:12]1[N:17]=[C:16]([C:18]#[N:19])[CH:15]=[C:14]([N+]([O-])=O)[CH:13]=1>>[Cl:11][C:12]1[N:17]=[C:16]([C:18]#[N:19])[CH:15]=[C:14]([O:8][C:7]2[C:2]([Cl:1])=[CH:3][CH:4]=[C:5]([CH3:10])[C:6]=2[F:9])[CH:13]=1

Participants

3

Reactant 2

HCID 27736846-Chloro-2-fluoro-3-methylphenolHCID 866449356-Chloro-4-nitro-2-pyridinecarbonitrile

Product 1

HCID 86644936HCID 86644936, compoundYield 88.2%

Procedure

The title compound was prepared in a similar manner to that described herein using 6-chloro-2-fluoro-3-methylphenol (0.60 g, 3.74 mmol) and 6-chloro-4-nitro-2-pyridinecarbonitrile (0.69 g, 3.74 mmol) to give the title compound as a white solid (0.98 g, 88%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 7.20-7.24 (1H, m) 7.16 (1H, d) 7.14 (1H, d) 6.98 (1H, d) 2.33 (3H, d). LCMS: m/z 297 (M+1).

Workup

  1. customThe title compound was prepared in a similar manner to that

Sources & evidence

ORD record
ord-015ef26154904a17b3c2694de9acb638
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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