反应详情

To a solution of 4-chloro-N-({4-chloro-3-[(3-chloro-5-ethynylphenyl)oxy]-2-fluorophenyl}methyl)-1-({[2-(trimethylsilyl)ethyl]oxy}methyl)-1H-imidazole-5-carboxamide (98.0 mg, 0.172 mmol) in DCM (5 ml) was added TFA (2.0 ml) and the reaction mixture was stirred at rt for 3 hours. The reaction was quenched with saturated sodium bicarbonate, diluted with EtOAc, and the organic layer was separated. The solvent was removed and the crude material was purified via silica gel chromatography to give 4-chloro-N-({4-chloro-3-[(3-chloro-5-ethynylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide (50.0 mg, 0.114 mmol, 66% yield) 1H NMR (400 MHz, DMSO-d6) δ ppm 8.09-8.30 (m, 1H), 7.73 (s, 1H), 7.45 (d, 1H), 7.22-7.36 (m, 2H), 7.08 (s, 1H), 6.88 (s, 1H), 4.49 (d, 2H), 4.37 (s, 1H). LC-MS (ES+) m/z 438.01, [M+H].

1. customThe reaction was quenched with saturated sodium bicarbonate
2. additiondiluted with EtOAc
3. customthe organic layer was separated
4. customThe solvent was removed
5. customthe crude material was purified via silica gel chromatography