反应详情

To a solution of bis(1,1-dimethylethyl)(4-chloro-5-{[({4-chloro-3-[(3-cyano-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)amino]carbonyl}-1H-imidazol-2-yl)imidodicarbonate (161 mg, 0.244 mmol) in DCM (5 ml) was added TFA (2.5 ml) and the reaction mixture was stirred at RT for 3 hours. The solvent was removed and the crude material was purified via reverse phase HPLC to give 2-amino-4-chloro-N-({4-chloro-3-[(3-cyano-5-cyclopropylphenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide trifluoroacetate (59 mg, 0.103 mmol, 42% yield).

1. customThe solvent was removed
2. customthe crude material was purified via reverse phase HPLC