HCID 178509940, compound → HCID 178509939, compound

HRID 1875215Notes

Reaction equation

HRID 1875215 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([C:12]2[NH:13][CH:14]=[C:15]([CH2:17][OH:18])[N:16]=2)=[O:11])=[C:4]([F:19])[C:3]=1[O:20][C:21]1[CH:26]=[C:25]([C:27]#[N:28])[CH:24]=[C:23]([Cl:29])[CH:22]=1>C(Cl)Cl.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:10]([C:12]2[NH:13][CH:14]=[C:15]([CH:17]=[O:18])[N:16]=2)=[O:11])=[C:4]([F:19])[C:3]=1[O:20][C:21]1[CH:26]=[C:25]([C:27]#[N:28])[CH:24]=[C:23]([Cl:29])[CH:22]=1

Participants

4

Reactant 1

HCID 178509940HCID 178509940, compound

Product 1

HCID 178509939HCID 178509939, compound

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6344DichloromethaneSolvent

Procedure

A solution of N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-(hydroxymethyl)-1H-imidazole-2-carboxamide (0.40 g, 0.92 mmol) and MnO2 (0.80 g, 9.2 mmol) in CH2Cl2 (10 mL) was stirred at RT for 2 h. The solution was filtered through celite and evaporated to provide the crude title compound which was used without further purification.

Workup

  1. filtrationThe solution was filtered through celite
  2. customevaporated

Sources & evidence

ORD record
ord-ecd6cf4fca3b4099a291a570f6bfda1c
Source dataset
uspto-grants-2012_11
Patent number
US08304419B2

Reaction notes

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