HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 178509940, compound → HCID 178509939, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 178509940 | HCID 178509940 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 178509939 | HCID 178509939 | — |
Reaction Steps
A solution of N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-4-(hydroxymethyl)-1H-imidazole-2-carboxamide (0.40 g, 0.92 mmol) and MnO2 (0.80 g, 9.2 mmol) in CH2Cl2 (10 mL) was stirred at RT for 2 h. The solution was filtered through celite and evaporated to provide the crude title compound which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08304419B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ecd6cf4fca3b4099a291a570f6bfda1c |
| Source note | uspto-grants-2012_11 |