Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) → HCID 68590100, compound

HRID 1875337Notes

Reaction equation

[Cl:1][C:2]1[S:6][C:5]([C:7]([NH:9][CH:10]2[CH:14]([O:15][CH3:16])[CH2:13][NH:12][CH2:11]2)=[O:8])=[CH:4][CH:3]=1.[CH3:17][CH:18]1[C:23]2[S:24][C:25]([C:27](O)=[O:28])=[N:26][C:22]=2[CH2:21][CH2:20][N:19]1[CH3:30].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>>[CH3:16][O:15][CH:14]1[CH2:13][N:12]([C:27]([C:25]2[S:24][C:23]3[CH:18]([CH3:17])[N:19]([CH3:30])[CH2:20][CH2:21][C:22]=3[N:26]=2)=[O:28])[CH2:11][CH:10]1[NH:9][C:7]([C:5]1[S:6][C:2]([Cl:1])=[CH:3][CH:4]=1)=[O:8]

Participants

Reactant 3

HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

HCID 58893836HCID 58893836, compound

HCID 68590734HCID 68590734, compound

Product 1

HCID 68590100HCID 68590100, compound

Procedure

Prepared analogously to Example 1b from (3SR,4SR)-3-[(5-chloro-thiophene-2-carbonyl)-amino]-4-methoxy-pyrrolidine and (RS)-4,5-dimethyl-4,5,6,7-tetrahydro-thiazolo[5.4-c]pyridine-2-carboxylic acid (prepared analogously to WO2004058728) with HATU as coupling reagent.

Sources & evidence

ORD record: ord-d58a43061edf42ecbf097573183d4466
Source dataset: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08309542B2

Reaction notes

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