Ethyl formate → N-(1-Methyl-2-thiophen-2-yl-ethyl)-formamide

HRID 1875344Notes

Reaction equation

HRID 1875344 reaction equation
[CH3:1][CH:2]([NH2:9])[CH2:3][C:4]1[S:5][CH:6]=[CH:7][CH:8]=1.[CH:10](OCC)=[O:11]>>[CH3:1][CH:2]([NH:9][CH:10]=[O:11])[CH2:3][C:4]1[S:5][CH:6]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 8025Ethyl formateHCID 64841332-(2-Aminopropyl)thiophene

Product 1

HCID 64990444N-(1-Methyl-2-thiophen-2-yl-ethyl)-formamide

Procedure

A solution of 5.9 g (33.4 mmol) 1-methyl-2-thiophen-2-yl-ethylamine in 34.8 ml (417.7 mmol) ethyl formate is refluxed for 16 hours. Then the mixture is cooled and evaporated to dryness i. vac.

Workup

  1. temperatureThen the mixture is cooled
  2. customevaporated to dryness i

Sources & evidence

ORD record
ord-eb1756aec0da40b2aba2bbccb88f8d1c
Source dataset
uspto-grants-2012_11
Patent number
US08309542B2

Reaction notes

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