Ammonia → HCID 86761675, compound

HRID 1875350Notes

Reaction equation

HRID 1875350 reaction equation
O=[C:2]1[CH:8]=[CH:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH:4]=[N:3]1.COS(OC)(=O)=O.[NH3:26]>>[NH:26]=[C:2]1[CH:8]=[CH:7][N:6]([C:9]([O:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:5][CH:4]=[N:3]1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 6497Dimethyl SulfateHCID 68588340HCID 68588340, compound

Product 1

HCID 86761675HCID 86761675, compound

Conditions

Temperature
90 °C

Procedure

1.0 g (4.0 mmol) benzyl 5-oxo-[1,4]diazepine-1-carboxylate are suspended in 1.0 ml (10.6 mmol) dimethylsulphate, stirred for two hours at 90° C. and after cooling dissolved in 10 ml (20 mmol) ammonia solution (2N in methanol). The mixture is stirred for 3.5 hours at RT and then evaporated to dryness.

Workup

  1. temperatureafter cooling
  2. stirringThe mixture is stirred for 3.5 hours at RT
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-945dbb7ee2c84bc4a92c8207f1607225
Source dataset
uspto-grants-2012_11
Patent number
US08309542B2

Reaction notes

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