Hydrazine hydrate (1:1) → HCID 178505622, compound

HRID 1875446Notes

Reaction equation

HRID 1875446 reaction equation
Cl[C:2]1[C:7]([C:8]#[C:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[F:16])=[N:6][CH:5]=[CH:4][N:3]=1.O.[NH2:18][NH2:19]>C(O)CCC>[F:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[CH2:9][C:8]1[C:7]2[C:2](=[N:3][CH:4]=[CH:5][N:6]=2)[NH:19][N:18]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59177859HCID 59177859, compound

Product 1

HCID 178505622HCID 178505622, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 550 mg (2.36 mmol) of 2-chloro-3-[(2-fluorophenyl)ethynyl]pyrazine from example 13A and 592 mg (11.8 mmol) of hydrazine hydrate in 12 ml of n-butanol is heated in a microwave at 140° C. for 30 min. The solution is then concentrated in vacuo, and the residue is purified by preparative HPLC. 150 mg (26% of theory) of the desired compound are obtained.

Workup

  1. concentrationThe solution is then concentrated in vacuo
  2. customthe residue is purified by preparative HPLC

Sources & evidence

ORD record
ord-4c901be2f80a41b094a1095575d691d4
Source dataset
uspto-grants-2012_11
Patent number
US08309551B2

Reaction notes

Loading…