反应详情

155 mg (0.55 mmol) of 3-(2-fluorobenzyl)imidazo[1,5-a]pyridine-1-carbohydrazide from example 16A are dissolved in 3 ml of methanol. 106 mg (0.65 mmol) of N,N′-carbonyldiimidazole are added, and the mixture is heated to reflux for 2 h. It is then purified directly by preparative HPLC to result in 98 mg (58% of theory) of the desired compound as a pale beige solid.

1. temperaturethe mixture is heated
2. temperatureto reflux for 2 h
3. customIt is then purified directly by preparative HPLC