Methanol → 5-[3-(2-Fluorobenzyl)imidazo[1,5-a]pyridin-1-yl]-1,3,4-oxadiazol-2(3H)-one

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Reaction Steps

155 mg (0.55 mmol) of 3-(2-fluorobenzyl)imidazo[1,5-a]pyridine-1-carbohydrazide from example 16A are dissolved in 3 ml of methanol. 106 mg (0.65 mmol) of N,N′-carbonyldiimidazole are added, and the mixture is heated to reflux for 2 h. It is then purified directly by preparative HPLC to result in 98 mg (58% of theory) of the desired compound as a pale beige solid.

Provenance & Evidence