Phosphorus oxychloride → 4-Chloro-6,7-dimethoxyquinazoline

HRID 1875489Notes

Reaction equation

HRID 1875489 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[CH:8][NH:7][C:6]2=O.P(Cl)(Cl)([Cl:18])=O>>[Cl:18][C:6]1[C:5]2[C:10](=[CH:11][C:12]([O:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=2)[N:9]=[CH:8][N:7]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 1354950166,7-Dimethoxy-3H-quinazolin-4-one

Product 1

HCID 27693644-Chloro-6,7-dimethoxyquinazolineYield 80%

Conditions

Temperature
105 °C

Procedure

In a 100 mL flask equipped with a reflux condenser, 6,7-dimethoxy-quinazolin-4-one 4.5 g (20 mmol), phosphoryl chloride (45 ml) were added. The mixture was stirred at 105° C. for 2 h, and then was poured into 100 mL of ice water carefully, and off-white squama solid was deposited slowly, which was filtered, dried and identified as the title compound. Yield: 80%.

Workup

  1. customIn a 100 mL flask equipped with a reflux condenser
  2. filtrationwhich was filtered
  3. customdried

Sources & evidence

ORD record
ord-579c29e9366c457f8ed82142be67944a
Source dataset
uspto-grants-2012_11
Patent number
US08309563B2

Reaction notes

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