3-Chloro-4-(3-fluorobenzyloxy)aniline → 6-Bromo-N-{3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}quinazolin-4-amine

Participants

Reaction Steps

6-bromo-4-chloro-quinazoline (1.36 g) and 3-chloro-4(m-fluoro-benzyloxy)-aniline (1.42 g) were dissolved into 50 mL of isopropanol. The mixture was reacted under reflux for 3 h, and a lot of yellow solid was deposited. The precipitated solid was filtered, and the filter cake was washed with cold ethanol and dried at 60° C. under vacuum overnight to obtain the 6-bromo-4-aminoquinazoline product (2.20 g, 86%).

Provenance & Evidence