反应详情

6-bromo-4-chloro-quinazoline (1.36 g) and 3-chloro-4(m-fluoro-benzyloxy)-aniline (1.42 g) were dissolved into 50 mL of isopropanol. The mixture was reacted under reflux for 3 h, and a lot of yellow solid was deposited. The precipitated solid was filtered, and the filter cake was washed with cold ethanol and dried at 60° C. under vacuum overnight to obtain the 6-bromo-4-aminoquinazoline product (2.20 g, 86%).

1. customThe mixture was reacted
2. temperatureunder reflux for 3 h
3. filtrationThe precipitated solid was filtered
4. washthe filter cake was washed with cold ethanol
5. customdried at 60° C. under vacuum overnight