HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic acid, 2-amino-5-iodo- → HCID 86600883, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | HCID 10384309 | HCID 10384309 | — |
| Reactant | HCID 22619321 | HCID 22619321 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 86600883 | HCID 86600883 | — |
Reaction Steps
The mixture of N-(2,6-dichlorobenzoyl)-4-amino-L-phenylalanine methylester (2.22 g), EDC/HCl (960 mg), HOBT (675 mg), triethylamine (834 μL), 2-amino-5-iodobenzoic acid (1.3 g) and dichloromethane (100 mL) was stirred overnight. The mixture was extracted with ethyl acetate and treated in accordance with the ordinary method to obtain a crude material of the intended compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309561B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e97b42245ea64b869d61c330d7bc8025 |
| Source note | uspto-grants-2012_11 |