反应详情

The mixture of N-(2,6-dichlorobenzoyl)-4-amino-L-phenylalanine methylester (2.22 g), EDC/HCl (960 mg), HOBT (675 mg), triethylamine (834 μL), 2-amino-5-iodobenzoic acid (1.3 g) and dichloromethane (100 mL) was stirred overnight. The mixture was extracted with ethyl acetate and treated in accordance with the ordinary method to obtain a crude material of the intended compound.

1. extractionThe mixture was extracted with ethyl acetate
2. additiontreated in accordance with the ordinary method