2,4-Difluorobenzoyl chloride → 2,4-difluorophenyl(3-(2,4-difluorophenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)methanone

HRID 1875568Notes

Reaction equation

HRID 1875568 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[N:13]2[CH2:14][CH2:15][NH:16][CH2:17][C:12]2=[CH:11][N:10]=1.[F:18][C:19]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:20]=1[C:21](Cl)=[O:22]>>[F:18][C:19]1[CH:27]=[C:26]([F:28])[CH:25]=[CH:24][C:20]=1[C:21]([N:16]1[CH2:15][CH2:14][N:13]2[C:9]([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])=[N:10][CH:11]=[C:12]2[CH2:17]1)=[O:22]

Participants

3

Reactant 2

HCID 5880812,4-Difluorobenzoyl chlorideHCID 341763183-(2,4-Difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-A]pyrazine

Product 1

HCID 444269632,4-difluorophenyl(3-(2,4-difluorophenyl)-5,6-dihydroimidazo[1,5-a]pyrazin-7(8H)-yl)methanone

Procedure

This compound 2 was prepared as described for Example 1 (Step H) starting from 50 mg of 3-(2,4-difluorophenyl)-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine (Step D) and 2,4-difluorobenzoyl chloride. Yield: 14 mgs, [M+H]+ 376.18.

Sources & evidence

ORD record
ord-bac43782a43b4a73a6be9e97c361cb4a
Source dataset
uspto-grants-2012_11
Patent number
US08309571B2

Reaction notes

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