1,3-Dibromopropane → HCID 11591329, compound

HRID 1875587Notes

Reaction equation

HRID 1875587 reaction equation
[N:1]12[CH2:8][CH2:7][C:4]([C:9]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[OH:10])([CH2:5][CH2:6]1)[CH2:3][CH2:2]2.[Br:23][CH2:24][CH2:25][CH2:26]Br>CC#N>[Br-:23].[Br:23][CH2:24][CH2:25][CH2:26][N+:1]12[CH2:6][CH2:5][C:4]([C:9]([OH:10])([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)([CH2:3][CH2:2]1)[CH2:7][CH2:8]2

Participants

4

Reactant 2

HCID 80011,3-DibromopropaneHCID 239923851-Azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol

Product 1

HCID 11591329HCID 11591329, compoundYield 43.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure outlined in Example 3, 1-azabicyclo[2.2.2]oct-4-yl(diphenyl)methanol (0.0979 g, 0.334 mmol) and 1,3-dibromopropane (0.35 mL, 3.448 mmol) in 2 CH3CN/3 CHCl3 (15.0 mL) were reacted to give the desired product (0.0712 g, 43.1%). EI-MS m/z 415 (M+) Rt (1.79 min).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-24722d7c03db46bcb8fbaeb2469f56d9
Source dataset
uspto-grants-2012_11
Patent number
US08309572B2

Reaction notes

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