Cyclopropanemethanol → 1-Cyclohexylmethyl-2-(2-cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole

HRID 1875721Notes

Reaction equation

HRID 1875721 reaction equation
Cl[C:2]1[C:7]([C:8]2[N:12]([CH2:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH:26]1([CH2:29][OH:30])[CH2:28][CH2:27]1>>[CH:14]1([CH2:13][N:12]2[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=[C:8]2[C:7]2[C:2]([O:30][CH2:29][CH:26]3[CH2:28][CH2:27]3)=[N:3][CH:4]=[CH:5][CH:6]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 75644CyclopropanemethanolHCID 866522862-(2-chloro-pyridin-3-yl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole

Product 1

HCID 510424861-Cyclohexylmethyl-2-(2-cyclopropylmethoxy-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole

Procedure

The title compound was prepared in analogy to Example 1, from 2-(2-chloro-pyridin-3-yl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole (Example 1, intermediate a) and cyclopropyl-methanol (CAS Reg. No. 2516-33-8). Colorless semi-solid (16%). MS (Turbo Spray): m/z=398.3 (M+H).

Sources & evidence

ORD record
ord-5cd17eed07e547ec8719d654ebb1c275
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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