4-Methoxybenzyl alcohol → HCID 67049968, compound

HRID 1875727Notes

Reaction equation

HRID 1875727 reaction equation
Cl[C:2]1[C:7]([C:8]2[N:12]([CH2:13][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=2)=[CH:6][CH:5]=[CH:4][N:3]=1.[CH3:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([CH2:34][OH:35])=[CH:30][CH:29]=1>>[CH:14]1([CH2:13][N:12]2[C:11]3[CH:20]=[C:21]([F:25])[C:22]([F:24])=[CH:23][C:10]=3[N:9]=[C:8]2[C:7]2[C:2]([O:35][CH2:34][C:31]3[CH:32]=[CH:33][C:28]([O:27][CH3:26])=[CH:29][CH:30]=3)=[N:3][CH:4]=[CH:5][CH:6]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 77384-Methoxybenzyl alcoholHCID 866522862-(2-chloro-pyridin-3-yl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole

Product 1

HCID 67049968HCID 67049968, compound

Procedure

The title compound was prepared in analogy to Example 4, intermediate, from 2-(2-chloro-pyridin-3-yl)-1-cyclohexylmethyl-5,6-difluoro-1H-benzoimidazole (Ex. 1, intermediate a) and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Colorless solid (31%). MS (Turbo Spray): m/z=464.2 (M+H).

Sources & evidence

ORD record
ord-f0fd7e503a47420ab4cf7e2725fb7d6a
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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