Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester → {4-[3-(1-Benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-yloxymethyl]-phenoxy}-acetic acid methyl ester

HRID 1875732Notes

Reaction equation

HRID 1875732 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([OH:25])=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:26][O:27][C:28](=[O:39])[CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([CH2:37]Br)=[CH:33][CH:32]=1>>[CH3:26][O:27][C:28](=[O:39])[CH2:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([CH2:37][O:25][C:20]2[C:19]([C:9]3[N:8]([CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)[C:12]4[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=4[N:10]=3)=[CH:24][CH:23]=[CH:22][N:21]=2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 67049717Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl esterHCID 178517705HCID 178517705, compound

Product 1

HCID 67050302{4-[3-(1-Benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-yloxymethyl]-phenoxy}-acetic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 5, intermediate a, from 3-(1-benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-ol and (4-bromomethyl-phenoxy)-acetic acid methyl ester (CAS Reg. No. 104508-23-8). Brown solid (65%). MS (Turbo Spray): m/z=516.3 (M+H).

Sources & evidence

ORD record
ord-ad1ec5e5678d467c90b01ddb2cd7378d
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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