HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester → {4-[3-(1-Benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-yloxymethyl]-phenoxy}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester | HCID 67049717 | — |
| Reactant | HCID 178517705 | HCID 178517705 | — |
| Product | {4-[3-(1-Benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-yloxymethyl]-phenoxy}-acetic acid methyl ester | HCID 67050302 | — |
Reaction Steps
The title compound was prepared in analogy to Example 5, intermediate a, from 3-(1-benzyl-5,6-difluoro-1H-benzoimidazol-2-yl)-pyridin-2-ol and (4-bromomethyl-phenoxy)-acetic acid methyl ester (CAS Reg. No. 104508-23-8). Brown solid (65%). MS (Turbo Spray): m/z=516.3 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-ad1ec5e5678d467c90b01ddb2cd7378d |
| Source note | uspto-grants-2012_11 |