4-Methoxybenzyl alcohol → HCID 67050020, compound

HRID 1875733Notes

Reaction equation

HRID 1875733 reaction equation
[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=2Cl)=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:34][O:35]C1C=CC(CO)=CC=1>>[CH2:1]([N:8]1[C:12]2[CH:13]=[C:14]([F:18])[C:15]([F:17])=[CH:16][C:11]=2[N:10]=[C:9]1[C:19]1[C:20]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][C:30]([O:35][CH3:34])=[CH:29][CH:28]=2)=[N:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 77384-Methoxybenzyl alcoholHCID 51042706HCID 51042706, compound

Product 1

HCID 67050020HCID 67050020, compound

Procedure

The title compound was prepared in analogy to Example 5, intermediate c, from 1-benzyl-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 6, intermediate) and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Colorless solid (72%). MS (Turbo Spray): m/z=458.1 (M+H).

Sources & evidence

ORD record
ord-deb7e31fe631441fb0304db5c140dde9
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

Loading…