Methyl 4-(hydroxymethyl)benzoate → 4-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-benzoic acid methyl ester

HRID 1875736Notes

Reaction equation

HRID 1875736 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:32]=[CH:33][CH:34]=1)[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([F:16])[C:13]([F:15])=[CH:14][C:9]=2[N:8]=[C:7]1[C:17]1[C:18]([O:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2Cl)=[N:19][CH:20]=[CH:21][CH:22]=1.[CH3:35][O:36][C:37](=[O:46])C1C=CC(CO)=CC=1>>[CH3:35][O:36][C:37](=[O:46])[C:28]1[CH:27]=[CH:26][C:25]([CH2:24][O:23][C:18]2[C:17]([C:7]3[N:6]([CH2:5][C:4]4[CH:32]=[CH:33][CH:34]=[C:2]([Cl:1])[CH:3]=4)[C:10]4[CH:11]=[C:12]([F:16])[C:13]([F:15])=[CH:14][C:9]=4[N:8]=3)=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:30][CH:29]=1

Participants

3

Reactant 2

HCID 81325Methyl 4-(hydroxymethyl)benzoateHCID 510394691-(3-Chloro-benzyl)-2-[2-(2-chloro-benzyloxy)-pyridin-3-yl]-5,6-difluoro-1H-benzoimidazole

Product 1

HCID 670500154-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-benzoic acid methyl ester

Procedure

The title compound was prepared in analogy to Example 4, intermediate, from 1-(3-chloro-benzyl)-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 11, intermediate) and 4-hydroxymethyl-benzoic acid methyl ester (CAS Reg. No. 6908-41-4). Colorless sticky solid (34%). MS (Turbo Spray): m/z=519.9 (M+H).

Sources & evidence

ORD record
ord-f5b069219054434bbdfa3de473e00ee6
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

Loading…