HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-(hydroxymethyl)benzoate → 4-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-benzoic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-(hydroxymethyl)benzoate | HCID 81325 | — |
| Reactant | 1-(3-Chloro-benzyl)-2-[2-(2-chloro-benzyloxy)-pyridin-3-yl]-5,6-difluoro-1H-benzoimidazole | HCID 51039469 | — |
| Product | 4-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-benzoic acid methyl ester | HCID 67050015 | — |
Reaction Steps
The title compound was prepared in analogy to Example 4, intermediate, from 1-(3-chloro-benzyl)-2-(2-chloro-pyridin-3-yl)-5,6-difluoro-1H-benzoimidazole (Example 11, intermediate) and 4-hydroxymethyl-benzoic acid methyl ester (CAS Reg. No. 6908-41-4). Colorless sticky solid (34%). MS (Turbo Spray): m/z=519.9 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-f5b069219054434bbdfa3de473e00ee6 |
| Source note | uspto-grants-2012_11 |