HRID1875737

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67049717

Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester

C10H11BrO3

结构：Oc1ncccc1-c1nc2cc(F)c(F)cc2n1Cc1cccc(Cl)c1

HCID178517707

未命名化合物

PRODUCTS

生成物

结构：COC(=O)COc1ccc(COc2ncccc2-c2nc3cc(F)c(F)cc3n2Cc2cccc(Cl)c2)cc1

HCID67049895

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to Example 5, intermediate a, from 3-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-ol and (4-bromomethyl-phenoxy)-acetic acid methyl ester (CAS Reg. No. 104508-23-8). Colorless powder (67%). MS (Turbo Spray): m/z=550.1 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-892b278ce7e54d3dadbd9292bea55672
来源数据集: uspto-grants-2012_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08309581B2
来源说明: uspto-grants-2012_11

反应 SMILES

[Cl:1][C:2]1[CH:3]=[C:4]([CH:24]=[CH:25][CH:26]=1)[CH2:5][N:6]1[C:10]2[CH:11]=[C:12]([F:16])[C:13]([F:15])=[CH:14][C:9]=2[N:8]=[C:7]1[C:17]1[C:18]([OH:23])=[N:19][CH:20]=[CH:21][CH:22]=1.[CH3:27][O:28][C:29](=[O:40])[CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38]Br)=[CH:34][CH:33]=1>>[CH3:27][O:28][C:29](=[O:40])[CH2:30][O:31][C:32]1[CH:37]=[CH:36][C:35]([CH2:38][O:23][C:18]2[C:17]([C:7]3[N:6]([CH2:5][C:4]4[CH:24]=[CH:25][CH:26]=[C:2]([Cl:1])[CH:3]=4)[C:10]4[CH:11]=[C:12]([F:16])[C:13]([F:15])=[CH:14][C:9]=4[N:8]=3)=[CH:22][CH:21]=[CH:20][N:19]=2)=[CH:34][CH:33]=1