HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester → (4-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-phenoxy)-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-[4-(bromomethyl)phenoxy]-, methyl ester | HCID 67049717 | — |
| Reactant | 3-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-ol | HCID 178517707 | — |
| Product | (4-{3-[1-(3-Chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-yloxymethyl}-phenoxy)-acetic acid methyl ester | HCID 67049895 | — |
Reaction Steps
The title compound was prepared in analogy to Example 5, intermediate a, from 3-[1-(3-chloro-benzyl)-5,6-difluoro-1H-benzoimidazol-2-yl]-pyridin-2-ol and (4-bromomethyl-phenoxy)-acetic acid methyl ester (CAS Reg. No. 104508-23-8). Colorless powder (67%). MS (Turbo Spray): m/z=550.1 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08309581B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-892b278ce7e54d3dadbd9292bea55672 |
| Source note | uspto-grants-2012_11 |