HCID 51042485, compound → 3-{4-[5,6-Difluoro-2-(2-hydroxy-pyridin-3-yl)-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester

HRID 1875741Notes

Reaction equation

HRID 1875741 reaction equation
C1(CN2C3C=C(F)C(F)=CC=3N=C2C2C(OCC3CCCC3)=NC=CC=2)CCCCC1.[CH3:32][O:33][C:34](=[O:71])[CH2:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([CH2:43][N:44]2[C:48]3[CH:49]=[C:50]([F:54])[C:51]([F:53])=[CH:52][C:47]=3[N:46]=[C:45]2[C:55]2[C:56]([O:61]CC3C=CC(OC)=CC=3)=[N:57][CH:58]=[CH:59][CH:60]=2)=[CH:39][CH:38]=1>>[CH3:32][O:33][C:34](=[O:71])[CH2:35][CH2:36][C:37]1[CH:38]=[CH:39][C:40]([CH2:43][N:44]2[C:48]3[CH:49]=[C:50]([F:54])[C:51]([F:53])=[CH:52][C:47]=3[N:46]=[C:45]2[C:55]2[C:56]([OH:61])=[N:57][CH:58]=[CH:59][CH:60]=2)=[CH:41][CH:42]=1

Participants

3

Reactant 2

HCID 51042485HCID 51042485, compoundHCID 670500353-(4-{5,6-Difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl ester

Product 1

HCID 1784998703-{4-[5,6-Difluoro-2-(2-hydroxy-pyridin-3-yl)-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester

Procedure

The title compound was synthesized in analogy to Example 5, intermediate b, from 3-(4-{5,6-difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl ester. Colorless solid (69%). MS (Turbo Spray): m/z=424.3 (M+H).

Sources & evidence

ORD record
ord-3fa044a454074256bc538fbe0fa520e0
Source dataset
uspto-grants-2012_11
Patent number
US08309581B2

Reaction notes

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