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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1875742Generated: October 31, 2026

4-Methoxybenzyl alcohol → 3-(4-{5,6-Difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl ester

https://huagongshe.com/reaction/1875742

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methoxybenzyl alcoholHCID 7738—
Reactant3-{4-[2-(2-Chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl esterHCID 86652288—
Product3-(4-{5,6-Difluoro-2-[2-(4-methoxy-benzyloxy)-pyridin-3-yl]-benzoimidazol-1-ylmethyl}-phenyl)-propionic acid methyl esterHCID 67050035—

Reaction Steps

The title compound was prepared in analogy to Example 4, intermediate, from 3-{4-[2-(2-chloro-pyridin-3-yl)-5,6-difluoro-benzoimidazol-1-ylmethyl]-phenyl}-propionic acid methyl ester and (4-methoxy-phenyl)-methanol (CAS Reg. No. 105-13-5). Colorless sticky solid (81%). MS (Turbo Spray): m/z=544.1 (M+H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08309581B2
Source datasetuspto-grants-2012_11
ORD IDord-da27f4c3222a4fc580c9f9df92b7197d
Source noteuspto-grants-2012_11